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Updated: Jul 27, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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结合组效应:从非胺酸沃里诺斯塔特类似物中吸取的教训

Silke Geurs1,2, Dorien Clarisse2,3, Karolien De Bosscher2,3

  • 1SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.

Journal of medicinal chemistry
|June 5, 2023
PubMed
概括

研究人员正在探索除酸之外的新结合组 (ZBGs) 对于激素脱乙酶抑制剂 (HDACi). 这种方法旨在提高癌症和炎症疾病治疗的安全性和有效性.

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Protein-Drug Binding: Mechanism and Kinetics

Protein-drug binding refers to the interaction between drugs and proteins within the body. This binding process can occur intracellularly, involving drug interactions with enzymes or receptors within cells, or extracellularly, involving plasma proteins in the blood.
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Drug binding to proteins is a key aspect of pharmacokinetics and can influence a drug's distribution, absorption, and elimination in the body. Several factors, including the drug's physiochemical properties, protein concentration, disease states, and the number of binding sites on the protein, influence this process.
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