从多中心艾滋病队列研究老年男性肺功能和生活质量与没有艾滋病毒从多中心艾滋病队列研究
Mona Abdo1, Ken M Kunisaki2,3, Alison Morris4
1Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
肺功能障碍,特别是一氧化碳扩散能力 (DLCO) 的降低,与男性的健康相关生活质量 (HRQoL) 降低和呼吸道症状恶化有关. 年龄显著影响这些关联.
科学领域:
- 肺部医学 肺部医学
- 艾滋病毒研究 艾滋病毒研究
- 生活质量研究 生命质量研究
背景情况:
- 与艾滋病毒感染者相比,艾滋病毒感染者往往会经历肺功能减弱和与健康相关的生活质量 (HRQoL) 的下降.
- 了解特定的肺功能障碍与HRQoL或呼吸系统健康状况之间的关系对于这一群体至关重要.
研究的目的:
- 为了研究肺功能障碍 (特别是一秒钟内一氧化碳[DLCO]扩散能力降低和强迫呼吸量[FEV1]) 与HRQoL或呼吸系统健康状况之间的关联.
- 探索年龄,艾滋病毒状况或吸烟是否会改变这些关联.
主要方法:
- 在多中心艾滋病队列研究 (2017-2019) 中对1048名男性的数据进行分析.
- 肺功能障碍定义为DLCO和FEV1<80%的预测.
- 评估结果使用HRQoL的36项简短形式调查 (SF-36) 和呼吸健康状况的圣乔治呼吸道问卷 (SGRQ).
- 调整后的分析采用了线性和零膨胀β回归模型.
主要成果:
- 损伤的DLCO,但不是FEV1,与较低的物理HRQoL显著相关.
- 肺功能障碍 (DLCO和FEV1) 与SGRQ限制的更高几率有关 (总分).
- 年龄改变了DLCO受损和呼吸限制之间的关联,在老年男性中观察到更强烈的效应. 艾滋病毒状况没有改变关联.
结论:
- 肺功能减弱,特别是DLCO,与老年男性的HRQoL较差和呼吸功能障碍增加有关.
- 年龄是DLCO损伤和呼吸系统健康之间的关系的显著影响修饰因素.
- 需要进一步的研究,以探索针对肺功能的干预措施,以改善艾滋病毒感染者和未感染者的HRQoL和呼吸系统健康.
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