在 (+) - 异溶酶醇的总合成过程中,
Jia-Tian Lu1, Yingxiao Zong1, Xiaodong Yue2
1Key Laboratory of Hexi Corridor Resources Utilization of Gansu, Hexi University, Zhangye 734000, P. R. China.
The Journal of organic chemistry
|June 5, 2023
概括
(+) - - 异色醇在18个步骤中被选择性合成. 关键步骤包括立体选择性子循环添加和催化取消,以形成核.
科学领域:
- 有机合成 有机合成
- 药用化学 医学化学
背景情况:
- (+) -isolysergol是一种有价值的藻类化物,具有潜在的治疗应用.
- 有效和立体选择性合成路径对于获得复杂的自然产品至关重要.
研究的目的:
- 开发一种新的,对 (+) -isolysergol.gol的选择性合成.
- 建立关键的合成转换来构建藻类化物核心结构.
主要方法:
- 采用了一种从 (2R) - - - - +) - 化开始的性池方法.
- 采用了对一个尼龙与一个终端烯的立体选择性分子内1,3-双极循环添加.
- 整合了Cope消除D环形成的方法.
- 开发了一种后期的催化分子内 [3 + 2] 解消,用于3,4合的内部支架.
主要成果:
- 在18个步骤中实现了 (+) - 异色醇的总合成.
- 获得了11%的总收益率,用于enantioselective合成.
- 成功构建了具有定义立体化学的四环藻类化物核心.
结论:
- 开发的合成策略为 (+) -isolysergol.gol提供了一条有效的路线.
- 关键的转换,特别是子循环添加和催化取消,对于构建复杂的含印醇天然产品非常有价值.
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