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554名墨西哥患有非综合征性口唇裂患者的表征:描述性研究

Araceli Pérez-González¹, Pilar Lavielle-Sotomayor², Larissa López-Rodríguez³

¹Department of Reconstructive Plastic Surgery, Mexican Charity for Children with Cleft Lip and Palate, ABC Medical Center.

The Journal of craniofacial surgery

|June 5, 2023

概括

面膜裂 (OFCs) 是一种常见的出生缺陷,在墨西哥人群中表现出各种风险因素. 叶酸摄入量和二度亲属的家族聚合是CL ± P和CP的统计学上显著的风险因素.

科学领域:

遗传学和流行病学
头骨面部形形面部形
公共卫生公共卫生

背景情况:

耳鼻裂 (OFC) 是一种普遍存在的出生缺陷,代表了全球最常见的面形.
带有或没有裂口的先天性裂口 (CL ± P) 和隔离裂口 (CP) 是最常见的OFC类型.
OFCs表现出多因素的病因,受遗传和环境因素的影响,发病率因地区和种族而异.

研究的目的:

调查与CL ± P和CP发展相关的潜在风险因素的频率.
分析墨西哥人口中OFCs与社会人口统计学,产前和家长史的关系.
为了确定在墨西哥队列中对OFCs有所贡献的重大风险因素.

主要方法:

一项涉及554名患者的横截面研究,针对OFC进行多系统治疗.
通过直接采访收集关于社会人口统计信息,产前和父母历史的数据.
统计分析以确定各种因素之间的关系和CL±P和CP的患病率.

主要成果:

在减少叶酸消费和OFCs发生之间发现了统计学上显著的关联 (P = 0.02).
在一级亲属中,OFCs的家族聚合没有统计学意义 (P = 0.34),但在二级亲属中是显著的 (P = 0.007).
554人中的大多数包括患有唇裂 (CLP) 的患者.

结论:

叶酸摄入量和二度亲属之间的家族聚合是墨西哥人口中 orofacial 裂的重要危险因素.
该研究强调需要进一步开展流行病学研究,以发现额外的风险因素,包括墨西哥人口中的特定遗传因素.
对OFC多因素病因的持续调查对于制定有效的预防和干预策略至关重要.

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