在生菜中的β-阻断剂的吸收和酶体选择性 (
Jiayao Xu1,2, Yu Wang2, Qiuyue Zhang2
1MOE Key Laboratory of Regional Environment and Eco-Restoration, College of Environment, Shenyang University, Shenyang 110044, China.
Journal of agricultural and food chemistry
|June 5, 2023
概括
贝塔抑制剂会积聚在生菜和番茄植物中,番茄的度更高. 这些药物对植物构成生态毒性风险,并通过蔬菜消费对人类健康构成潜在风险.
科学领域:
- 环境化学环境化学
- 植物科学 植物科学
- 生态毒理学 生态毒理学
背景情况:
- 在环境中越来越多地检测到药物,包括β抑制剂.
- 了解它们在食用植物中的命运对于评估生态和人类健康风险至关重要.
研究的目的:
- 为了研究在生菜和西红中特定β-阻断剂 (atenolol,sotalol,propranolol) 的吸收和转移.
- 评估这些药品在植物中的生物度和转移因子.
- 评估与食用污染蔬菜相关的潜在风险.
主要方法:
- 进行了一项为期70天的土种植实验,使用了和西红.
- 测量了根吸收,生物度因子 (BCFroot/土壤) 和转移因子.
- 分析了可食用部分中的β-阻断剂的反体概况.
主要成果:
- 在生菜根中β-阻断剂的吸收随着水溶性降低而降低 (atenolol > sotalol > propranolol).
- 番茄根中的生物度高于生菜中的生物度.
- 阿提诺洛尔和普拉诺洛尔显著转移到西红的上空部分.
- 番茄果实中的反复体形状转向更有毒的形式.
结论:
- β抑制剂在食用植物中表现出不同的吸收和转移,受物理化学性质的影响.
- 在蔬菜中β-阻断剂的存在和反体转移表明潜在的生态毒性和人类暴露风险.
- 需要进一步的研究,才能充分了解药物污染对食品链的长期影响.
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