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拾荒受体B2,一种III型膜模式识别受体,感知LPS并激活甲类的IMD通路

Xiu-Zhen Shi¹, Ming-Chong Yang^1,2, Xin-Le Kang¹

¹Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.

Proceedings of the National Academy of Sciences of the United States of America

|June 5, 2023

概括

研究人员发现了一种新的食者受体SRB2,它激活了免疫缺陷 (IMD) 途径. 这一发现解释了甲如何对抗细菌感染,并增强了对预防病的先天免疫力的理解.

科学领域:

* 具有天生的免疫力
* 甲动物生物学
* 分子信号传递途径

背景情况:

*免疫缺陷 (IMD) 途径对于昆虫和甲类动物的宿主防御至关重要.
*类IMD通路激活机制因缺少关键识别蛋白而与昆虫有所不同.

研究的目的:

* 确定负责激活甲类动物IMD通路的特定受体.
*为了阐明Marsupenaeus japonicus中IMD通路激活的分子机制.

主要方法:

* 在Marsupenaeus japonicus中识别和表征一个食尸体受体 (SRB2).
*分析细菌挑战时的SRB2表达和功能.
* 研究SRB2与细菌脂多糖 (LPS) 和IMD通路组件的相互作用.
*在Drosophila melanogaster S2细胞中进行功能测定,以确认SRB2的作用.

主要成果:

*SRB2被确定为激活中的IMD通路的受体.
*随着细菌的挑战,SRB2的表达增加,其枯竭导致死亡率和细菌负载增加.
*SRB2识别LPS,与IMD相互作用,并促进RELISH核转位,诱导抗菌.
*SRB2的过度表达增强了Drosophila细胞中LPS诱导的IMD通路激活.

结论:

* 一个新的SRB2-IMD信号轴负责抗微生物诱导和类动物的细菌感染控制.
* 这项研究揭示了动物物种间IMD信号的生物多样性.
* 了解甲动物的天生的免疫力可以帮助制定对病的策略.

关键词:

在IMD信号通路中,IMD信号通路抗微生物是一种抗微生物.甲类的甲类动物.模式识别受体是一种模式识别受体.拾尸体受体的受体拾尸体受体

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