术后脊柱18 F-FDG PET伪进展模仿恶性病变
Penghao Liu, Jing Huang1, Jie Lu
1Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Clinical nuclear medicine
|June 5, 2023
概括
这项研究强调了初始脊柱成像如何可能误诊质结晶症为恶性瘤. 定子发射断层扫描 (PET) 扫描可以显示伪进展,需要仔细解释以避免不必要的治疗.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 一名60岁的妇女经历了左上肢的软弱,这促使她进行了最初的脊柱核磁共振.
- 最初的MRI发现了一个C2-C3异质质量,在18F-FDGPET扫描上没有显示异常活动.
- 手术切除揭示了质,而不是恶性病,但患者的症状持续并恶化.
研究的目的:
- 为了调查在最初的脊髓质切除后,四肢衰弱的复发和恶化的原因.
- 评估包括18F-FDG PET和18F-FET PET在内的先进成像技术在区分手术后的变化与真正的疾病进展中的实用性.
- 确定脊髓内脊髓病变的最终诊断和适当的管理策略.
主要方法:
- 最初的脊柱MRI和18F-FDG PET-CT.
- 手术切除和组织病理学检查.
- 随访脊柱MRI,18F-FDG PET-CT,以及18F-FET PET-CT. 这两种检查是最有效的.
- 宫脊椎活检 (C2-C4) 用于他的病理学确认.
主要成果:
- 最初的C2-C3质量被诊断为切割后的质病.
- 手术后的症状导致进一步的成像显示出更大的骨髓内质量 (长髓到C5).
- 复发性质量显示高18F-FDG吸收 (SUV最大7.11),但只有轻度的18F-FET吸收 (SUV最大2.29).
- 活检证实了结质病,而PET发现被解释为伪进展.
结论:
- 质症可以呈现为异质的脊髓质量,并在成像上模仿恶性进展.
- 18F-FDG PET高新陈代谢可能代表伪进展,特别是在术后变化的背景下.
- 18F-FET PET可能会提供额外的信息来区分反应性质瘤与真正的瘤过程.
- 仔细整合临床,放射学和病理学发现对于准确的诊断和管理至关重要.
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