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Updated: Jul 27, 2025

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基于DCAF16的CDK4/6的PROTAC降解探针的开发基于DCAF16的研究

Chunlan Pu1, Yuanyuan Liu2, Rui Deng3

  • 1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China; Medical Research Center, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, Sichuan 610031, China.

Bioorganic chemistry
|June 5, 2023
PubMed
概括

一种基于DCAF16的新型化合物A4有效地向并降低三阴性乳腺癌 (TNBC) 细胞中的循环素依赖激酶4/6 (CDK4/6) 蛋白水平. 这种新的降解剂显示出治疗潜力,毒性低于现有治疗方法.

关键词:
在CDK4/6中使用.在 DCAF16 中使用.降解降解是一种降解.这就是PROTAC.美国TNBC电视台

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