Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

6.6K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.6K
Variation of Atmospheric Pressure01:18

Variation of Atmospheric Pressure

2.3K
Change in atmospheric pressure with height is particularly interesting. The decrease in atmospheric pressure with increasing altitude is due to the decreasing gravitational force per unit area as we move away from the surface of the earth.
Assuming the air temperature is constant at a given altitude and that the ideal gas law of thermodynamics describes the atmosphere to a good approximation, one can find the variation of atmospheric pressure with height.
Let p(y) be the atmospheric pressure at...
2.3K
Sound Intensity00:58

Sound Intensity

4.1K
The loudness of a sound source is related to how energetically the source is vibrating, consequently making the molecules of the propagation medium vibrate. To measure the loudness of a source, the physical quantity of interest is the intensity. This is defined as the energy emitted per unit of time per unit of area perpendicular to the sound wave's propagation direction. Since the total energy is greater if the source vibrates for a longer duration and over a larger area, dividing the...
4.1K
Sound Intensity Level00:53

Sound Intensity Level

4.2K
Humans perceive sound by hearing. The human ear helps sound waves reach the brain, which then interprets the waves and creates the perception of hearing. The loudness of the environment in which a person is located determines whether they can distinguish between different sound sources.
The human ear can perceive an extensive range of sound intensity, necessitating the use of the logarithmic scale to define a physical quantity—the intensity level. It is a ratio of two intensities and...
4.2K
Dimensions of Health and Illness01:21

Dimensions of Health and Illness

7.5K
The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
7.5K
Thermodynamic Systems01:06

Thermodynamic Systems

5.2K
A thermodynamic system is a set of objects whose thermodynamic properties are of interest. The system is considered to be embedded in its surroundings or the environment. The system and its environment can exchange heat and do work on each other through a boundary that separates them. However, the immediate surroundings of the system interact with it directly and therefore have a much stronger influence on its behavior and properties.
Consider an example of  tea boiling in a kettle. The...
5.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Mapping Multiscale Brain Changes in Primary Angle-Closure Glaucoma Using Regional Radiomics Similarity Networks.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same author

Oral health-related quality of life, associated factors, and oral-psychological burden profiles among people living with HIV: a cross-sectional study.

BMC oral health·2026
Same author

The role of CD8<sup>+</sup> T cells in the immunoregulation of osteoporosis.

Frontiers in immunology·2026
Same author

From positive psychology to practical empowerment: theoretical construction and pathway innovation in graduate student mental health education.

Frontiers in psychology·2026
Same author

Buffering the constraint: exploring the role of TOE in supporting enterprise digital transformation in resource-based cities.

Scientific reports·2026
Same author

Multi-omics study on traditional Xiaoqu of Fangxian Huangjiu: Unveiling interactions among physicochemical factors, microbiome and volatile flavor compounds.

Food chemistry: X·2026

相关实验视频

Updated: Jul 27, 2025

Production and Measurement of Organic Particulate Matter in the Harvard Environmental Chamber
09:46

Production and Measurement of Organic Particulate Matter in the Harvard Environmental Chamber

Published on: November 18, 2018

7.3K

环境 NO NO 环境

Shuzi Ye1, Yu Ma1, Siwen Li1

  • 1Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha 410078, China.

Journal of hazardous materials
|June 5, 2023
PubMed
概括
此摘要是机器生成的。

二氧化 (NO2) 暴露会阻碍中性粒细胞外细胞陷 (NETs) 的形成,这是一个关键的免疫反应. 这项研究揭示了NO2损害关键信号通路和自,影响宿主对病原体的防御.

关键词:
自自是一种自的过程.甲基因激活蛋白激酶 (MAPK) 信号传导中性粒细胞外细胞陷 (NETs)氨基酸3-激酶 (PI3K) -蛋白激酶B (AKT) 信号传导反应性氧物种 (ROS) 是一种反应性氧物种.

更多相关视频

An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research
06:16

An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research

Published on: February 2, 2022

2.5K
Author Spotlight: Unraveling the Mysteries of Terrestrial Anaerobic Microorganisms in Uncharted Environments by In Situ Culturing
07:56

Author Spotlight: Unraveling the Mysteries of Terrestrial Anaerobic Microorganisms in Uncharted Environments by In Situ Culturing

Published on: January 12, 2024

962

相关实验视频

Last Updated: Jul 27, 2025

Production and Measurement of Organic Particulate Matter in the Harvard Environmental Chamber
09:46

Production and Measurement of Organic Particulate Matter in the Harvard Environmental Chamber

Published on: November 18, 2018

7.3K
An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research
06:16

An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research

Published on: February 2, 2022

2.5K
Author Spotlight: Unraveling the Mysteries of Terrestrial Anaerobic Microorganisms in Uncharted Environments by In Situ Culturing
07:56

Author Spotlight: Unraveling the Mysteries of Terrestrial Anaerobic Microorganisms in Uncharted Environments by In Situ Culturing

Published on: January 12, 2024

962

科学领域:

  • 免疫学 免疫学 免疫学
  • 环境健康 环境健康
  • 细胞生物学 细胞生物学

背景情况:

  • 二氧化 (NO2) 是一种已知的免疫毒剂,增加了对感染的易感性.
  • 中性粒细胞通过中性粒细胞外细胞陷 (NETs) 在宿主防御中发挥着至关重要的作用.
  • 二氧化物对中性粒细胞功能,特别是NET形成的特定影响仍然未得到充分研究.

研究的目的:

  • 研究NO2暴露对中性粒细胞外细胞陷 (NET) 形成的影响.
  • 阐明NO2影响NETosis的潜在分子机制.
  • 探索潜在的治疗干预措施,以防止NO2诱导的免疫毒性.

主要方法:

  • 对中性粒细胞暴露在10 ppm NO2中,持续15天.
  • 分析NET形态和组件的分析.
  • 使用NO2衍生物的体外和体外研究.
  • 呼吸突发的评估,MAPK/PI3K-AKT信号通道.
  • 对自标志物 (mTOR,LC3) 和自囊泡的评估.
  • 用拉帕 (Rapa) 治疗以调节自.

主要成果:

  • 暴露于NO2显著阻碍了NET的形成.
  • NO2抑制了呼吸突发和抑制了MAPK/PI3K-AKT信号通路.
  • NO2诱导的NET抑制与自身食功能受损有关,由改变的mTOR和LC3表达证实.
  • 拉巴胺治疗逆转了PMA诱导的NET形成的NO2介导抑制.

结论:

  • 通过抑制关键信号和自途径来抑制NET形成,NO2暴露会损害中性粒细胞的功能.
  • 这些发现提供了对NO2免疫毒性及其在疾病病因学中的作用的见解.
  • 向自可能提供一种保护策略,防止NO2诱导的免疫功能障碍.