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在初级中枢神经系统淋巴瘤的管理方面的挑战

Xuefei Sun¹, Liwei Lv¹, Yuchen Wu¹

¹Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Critical reviews in oncology/hematology

|June 5, 2023

概括

初级中枢神经系统淋巴瘤 (PCNSL) 治疗正在通过新药和巩固疗法取得进展. 对PCNSL的最佳整合策略需要进一步研究,以改善长期存活率并减少复发.

科学领域:

在瘤学瘤学.
神经学神经学
血液学血液学血液学

背景情况:

初级中枢神经系统淋巴瘤 (PCNSL) 是一种罕见的,侵袭性的非霍奇金淋巴瘤.
立体活检是PCNSL诊断的黄金标准,有新兴的辅助方法,如细胞因子和循环瘤DNA分析.
尽管新型疗法取得了进展,但高复发率和死亡率仍然是一个重大挑战.

研究的目的:

审查PCNSL目前的诊断方法.
讨论PCNSL治疗的进展,包括新药和巩固疗法.
突出关于PCNSL最佳整合战略的不确定性和研究需求.

主要方法:

对PCNSL诊断和治疗现有文献的综述.
专注于巩固治疗方式:全脑放射疗法,自身造血干细胞移植和非骨髓破坏性化疗.
分析有关不同整合方法的有效性和安全性的现有证据.

主要成果:

新型治疗药物如免疫调节剂,免疫检查点抑制剂,CAR T细胞和BTK抑制剂显示出有前途.
巩固治疗,包括放射治疗和干细胞移植,对于改善结果至关重要.
关于整合策略的直接比较研究有限,使最佳方法不确定.

结论:

通过新的辅助方法,PCNSL诊断正在不断发展.
虽然新型全身疗法提供了希望,但巩固治疗对于管理PCNSL至关重要.
进一步的研究是必不可少的,以确定最有效和安全的整合策略,以实现长期的PCNSL生存.

关键词:

整合计划的整合方案诊断诊断诊断诊断诊断诱导计划的诱导方案管理管理管理管理主要中枢神经系统淋巴瘤

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