组合式3D打印剂型,用于两步和受控的药物释放.
Christos S Katsiotis1, Evgenii Tikhomirov1, Maria Strømme1
1Division of Nanotechnology and Functional Materials, Department of Materials Science and Engineering, Uppsala University, Box 35, Uppsala SE-751 03, Sweden.
概括
这项研究结合了化沉积建模 (FDM) 和选择性激光烧结 (SLS) 增材制造,以创建可调节的药物输送设备. 混合方法提供受控的理论素释放,克服了单个AM方法的局限性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 沉积建模 (FDM) 和选择性激光烧结 (SLS) 是药物研究中的关键增材制造 (AM) 技术.
- 现有的AM方法存在局限性,需要开发先进的,用于药物输送的组合系统.
研究的目的:
- 开发和评估混合增材制造系统,将SLS插件和FDM外结合起来,用于控制药物释放.
- 为了证明这些混合系统在可调节的神素药物输送方面的潜力.
主要方法:
- 混合药物输送装置的制造,使用SLS作为插件和FDM作为两外.
- 将西奥菲林作为一种模型药物纳入SLS插件中.
- 通过不同的烧结参数和插入组合来表征药物无形化,剂量和释放动力学.
主要成果:
- 选择性激光烧结 (SLS) 诱导了理论素的部分无形化,对溶解不良的药物有益.
- 烧结参数有效控制了SLS插件中的药物剂量和释放动力学.
- 在FDM外内的SLS插件组合使药物释放形状多样化,包括两步和延长释放模式.
结论:
- 结合SLS和FDM增材制造,提供了一个模块化方法来克服个别技术的局限性.
- 混合AM系统为开发先进的制药药物输送设备提供了一个高度可调的平台.
- 这项概念验证研究验证了混合AM在精确控制药物释放特征方面的潜力.
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