开发氧化发生器,以产生高剂量的氧化用于吸入治疗
Binglan Yu1, Hatus V Wanderley1, Stefano Gianni1
1Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
三种新设备可以安全地产生高剂量的氧化物 (NO) 超过100ppm,低氧化物 (NO2) 含量. 这些高度的NO生成器显示出治疗呼吸道感染的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 呼吸系统医学 呼吸系统医学
- 医疗器械开发 医疗器械开发
背景情况:
- 氧化 (NO) 吸入疗法用于高达80ppm的度.
- 高剂量的NO (>100 ppm) 可能具有抗菌作用,但其可行性和安全性尚未确定.
- 需要新的NO产生装置来探索高剂量NO的应用.
研究的目的:
- 设计,开发和测试三种新型高剂量氧化 (NO) 生产装置.
- 评估生产超过100 ppm的NO度的可行性和安全性.
- 在各种操作条件下评估NO和二氧化 (NO2) 水平.
主要方法:
- 开发了三种不同的NO发电机:双点火塞,高压单点火塞和滑动弧.
- 在不同的气体流量和大气压力下测量NO和NO2度.
- 测试了带有呼吸机和人工肺的设备,以模拟临床使用,比较能源消耗.
主要成果:
- 双点火栓发电机产生高达320 ppm的NO,NO2<3 ppm.
- 高压发电机在2.0ATA时达到407ppm的NO,而NO2在连接到通风机时低于1ppm.
- 滑动弧形发电机产生高达180ppm的NO,NO2<1ppm,但需要更高的能源消耗.
结论:
- 开发了三种可行的高剂量NO产生装置,能够产生100ppm以上的NO.
- 在各种设备和条件下保持低NO2水平 (<3ppm).
- 这些设备为未来研究高剂量吸入NO的呼吸道感染提供了潜力.
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