颗粒物,与交通有关的空气污染物,以及循环中的C反应蛋白水平:多民族队列研究
Meera Sangaramoorthy1, Juan Yang1, Chiuchen Tseng2
1Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, CA, USA.
Environmental pollution (Barking, Essex : 1987)
|June 5, 2023
概括
暴露于与交通有关的空气污染,包括颗粒物 (PM) 和氧化 (NOx),与不同人群中更高的全身炎症 (CRP) 有关. 这些影响在拉丁裔个人和来自较低社会经济背景的人群中更为明显.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 吸入的污染物会引发慢性炎症,影响健康.
- 很少有研究探讨空气污染对不同的人口和生活方式的炎症影响.
- 由C-反应蛋白 (CRP) 表示的全身炎症是一个关键的健康问题.
研究的目的:
- 调查与交通相关的空气污染和CRP水平之间的联系.
- 检查这些跨种族/种族,社会经济地位和生活方式因素的关联.
- 在多民族群体中评估空气污染炎症影响的普遍性.
主要方法:
- 在多民族队列 (MEC) 研究 (1994-2016) 中利用了来自加利福尼亚州7,860名居民的数据.
- 使用住宅地址估计暴露于PM2.5,PM10,PM10-2.5,NOx,CO,臭氧和.
- 通过血液样本分析CRP水平,并使用多变量通用线性回归计算估计污染物影响.
主要成果:
- 对PM10,PM10-2.5,NOx和的12个月暴露显示出与CRP水平增加的显著关联.
- 在拉丁裔参与者,低社会经济水平的社区和超重/肥胖个体中观察到关联.
- 对于1个月的污染物暴露,没有发现一致的模式.
结论:
- 与交通有关的空气污染物,包括PM和NOx,与全身炎症 (CRP) 有关.
- 这些关联在多民族人口和特定子群体中很明显.
- 研究结果强调了空气污染对不同人群炎症的广泛影响.
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