环类纳米管作为一种新的潜在药物输送系统:特征和生物相容性
Ladan Dayani1, Mehdi Aliomrani2, Hossein Hashempour3
1Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
International journal of pharmaceutics
|June 5, 2023
概括
环类纳米管表现出了显著的稳定性和生物相容性. 这些自组装的循环结构显示出在生物应用中作为新型载体的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 类化学 类化学
背景情况:
- 环酸是以自我组装特性而闻名的循环酸.
- 纳米管为各种应用提供独特的结构和功能特性.
- 了解自组装环类纳米管的特性对于它们的潜在用途至关重要.
研究的目的:
- 为了描述环类纳米管的特性.
- 评估这些纳米结构的稳定性和形态.
- 评估循环胺纳米管的细胞兼容性和体内安全性.
主要方法:
- 差分扫描热度计 (DSC) 对于热稳定性.
- 库马林作为一种用于形态识别的光探针.
- 场辐射扫描电子显微镜 (FESEM) 用于长期稳定性评估.
- 对外围血液单核细胞的细胞毒性测定.
- 在体内对C57BL/6小鼠进行的研究,包括完整的血清分析.
主要成果:
- 循环化物纳米管通过DSC证明了高达200°C的稳定性.
- 光显微镜证实了库马林在自组装的循环结构中的封装.
- FESEM分析显示,纳米管稳定性在3个月后在-20°C下保持.
- 细胞毒性和体内研究证实了环类纳米管的生物相容性.
结论:
- 自组装的环化物纳米管在热和物理上都很稳定.
- 这些纳米管在体外和体外表现出极好的生物相容性.
- 环化物纳米管是生物应用的有希望的新型生物相容载体.
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