高SNRPA1表达导致肺腺癌患者的预后不佳
Juan Juan Yang1,2, Yu Jia Yang2, Yi Lu Gu2
1Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
The clinical respiratory journal
|June 5, 2023
概括
结合体子单元SNRPA1在肺腺癌 (LUAD) 中被上调,与预后不佳相关. 抑制SNRPA1会减少LUAD细胞的生长和迁移,这表明它是一个潜在的治疗点.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 结合体子单元SNRPA1与各种癌症有关.
- 它在肺腺癌 (LUAD) 中的作用尚不清楚.
研究的目的:
- 调查SNRPA1在LUAD中的预后价值.
- 阐明SNRPA1在LUAD中的功能背后的分子机制.
主要方法:
- 对预后价值进行TCGA数据库分析.
- qRT-PCR和免疫组织化学用于表达分析.
- 在体外测定 (增殖,迁移,EMT) 和免疫微环境分析.
主要成果:
- 在LUAD组织和细胞系中,SNRPA1被上调.
- 高SNRPA1表达与LUAD患者预后不佳相关.
- 抑制SNRPA1抑制了LUAD细胞的增殖,迁移和上皮-介质细胞转换 (EMT).
- SNRPA1与免疫细胞透和免疫检查点有关.
结论:
- SNRPA1 作为 LUAD 的潜在预后生物标志物.
- SNRPA1代表了LUAD治疗的潜在治疗标.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.7K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K