加速度计测量强度特定的体力活动,遗传风险和发生的2型糖尿病:一个前性队列研究
Mengyun Luo1,2,3, Chenhao Yu3, Borja Del Pozo Cruz4,5,6
1Prevention Research Collaboration, Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
British journal of sports medicine
|June 5, 2023
概括
定期体育活动,特别是中度至强度运动 (MVPA),显著降低了2型糖尿病的风险,即使具有高遗传倾向. 增加的MVPA提供了没有明确最低或最高门的好处,为未来的预防策略提供了信息.
科学领域:
- 流行病学 流行病学
- 预防医学 预防医学
- 遗传学 是一个遗传学.
背景情况:
- 目前的2型糖尿病 (T2D) 预防指南建议每天进行30分钟的中等强度体力活动,但往往忽视遗传风险因素.
- 使用加速度计测量身体活动的目标提供了比自我报告更准确的评估.
研究的目的:
- 调查身体活动 (总和强度特定) 和T2D事件之间的剂量反应关系.
- 根据不同水平的T2D遗传风险来考虑和分层分析.
主要方法:
- 一项前性队列研究,对59,325名英国生物库参与者 (平均年龄61.1岁) 进行加速计测量体力活动.
- 与T2D发病率的国家登记处相关的数据截至2021年9月.
- 考克斯的比例危险模型和受限制的立方线用于分析关联,根据多基因风险得分进行调整和分层.
主要成果:
- 在中度至强烈强度的体力活动 (MVPA) 和降低T2D风险之间观察到强烈的,线性剂量反应相关性,独立于遗传风险.
- 较高的MVPA水平显示T2D发病率的危险比率明显较低 (例如,与HR 0.26相关的> 68.4分钟/天).
- MVPA和遗传风险评分之间的显著添加相互作用表明,在遗传高风险个体中,使用MVPA可以减少更大的绝对风险.
结论:
- 促进体力活动,特别是MVPA,对于预防T2D至关重要,特别是对于具有高遗传倾向的个体.
- MVPA的好处似乎是连续的,没有可识别的最小或最大有效门.
- 这些发现支持更新T2D预防指南和制定有针对性的干预措施.
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