在脊髓中以整合素驱动的轴突再生激活了独特的中枢神经系统再生程序
Menghon Cheah1, Yuyan Cheng2, Veselina Petrova3
1John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, United Kingdom.
概括
科学家们在感觉神经元中发现了一种新的中枢神经系统 (CNS) 再生程序. 这种涉及分子运输和自的程序对于脊髓损伤后的轴突再生至关重要.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 再生医学是一种再生医学.
背景情况:
- 周围的感觉神经元很容易再生,但脊髓中的中央轴突却没有.
- α9整合素和kindlin-1 (α9k1) 表达可以通过与tenascin-C相互作用来促进中央轴突再生.
研究的目的:
- 阐明α9k1诱导的中枢神经系统 (CNS) 再生激活的分子机制和下游途径.
- 确定促进中枢神经系统感官轴突再生的新目标.
主要方法:
- 成年大鼠背部根 (DRG) 感觉神经元的转录组分析,用α9k1转换,有或没有中央轴切.
- 药理上抑制已确定的与再生相关的途径.
- 使用人类诱导多能干细胞 (iPSC) 衍生的感觉神经元进行验证.
主要成果:
- α9k1的表达上调了一个周围神经系统 (PNS) 再生程序.
- 合α9k1与中央轴切引发了广泛的中枢神经系统轴突再生.
- 一个独特的中枢神经系统再生计划出现了,涉及到无处不在,自,ER调制,贩运和信号,由药理抑制因果验证.
- 这个中枢神经系统程序与胚胎发育和PNS再生程序有很大的不同.
结论:
- 集成信号使感官神经元能够进行再生.
- 中枢神经系统中的轴突生长需要一个与PNS再生分开的独特的分子程序.
- 已确定的分子通路 (无处不在,自,ER,贩运,信号) 对于中枢神经系统的感觉轴突再生至关重要.
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