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基于石化的微环传感器阵列的并行查询用于光声断层扫描.

Jingshun Pan^1,2,3, Qiang Li¹, Yaoming Feng¹

¹School of Electronics and Information Technology, Guangdong Provincial Key Laboratory of Optoelectronic Information Processing Chips and Systems, Sun Yat-sen University, Guangzhou, 510275, China.

Nature communications

|June 5, 2023

概括

这项研究引入了一种新的光声断层扫描 (PAT) 系统,使用基于石化的微环传感器阵列和数字光学频率 (DOFC) 进行并行查询. 这一进步使动态生物样本的高分辨率成像能够提高效率.

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科学领域:

生物医学光学生物医学光学
声学成像声学成像
传感器技术传感器技术

背景情况:

光声断层扫描 (PAT) 提供光学对比度与声学分辨率,对于先进的生物医学成像至关重要.
在PAT的进展严重依赖于复杂的超声波传感器阵列.
芯片上的光学超声波传感器看起来很有希望,但在PAT系统中尚未得到充分探索.

研究的目的:

为了证明光声学断层扫描 (PAT) 使用一种新的基于石化的微环传感器阵列.
开发和验证使用数字光学频率 (DOFC) 的传感器阵列的并行查询方法.
展示系统在成像动态和生物对象的能力.

主要方法:

制造和表征一个基于15元素石化的微环传感器阵列,具有高灵敏度和宽带宽.
数字光学频率 (DOFC) 的合成,用于对传感器阵列进行并行光学查询.
使用开发的传感器阵列和DOFC实现PAT用于成像概念验证样本.

主要成果:

传感器阵列显示带宽为175 MHz,噪声等价压力为2.2 mPaHz-1/2.2.
通过单个光源和光接收器成功实现了并行审讯.
获得了快速移动的物体,叶脉和活斑马鱼的高质量PAT图像.

结论:

基于石化的微环传感器阵列为PAT应用提供了卓越的性能.
支持DOFC的并行查询为PAT系统提供了有效和高效的方法.
这种综合方法显著提高了PAT在各种成像应用中的潜力.