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Won Jeong Cho¹, Yitak Kim¹, Jung Dong Kim¹

¹Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.

Scientific reports

|June 5, 2023

概括

类固醇注射可以通过类固醇诱导的眼睛高血压 (SIOH) 引起失明. 通过AS-OCT测量较短的椎间板状网状网 (TM) 高度与SIOH风险有关. 患有TM高度<646.75μm的患者需要谨慎.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
药理学药理学是指药理学的学科.

背景情况:

类固醇注射用于治疗各种眼睛疾病.
类固醇诱导的眼睛高血压 (SIOH) 是可能导致不可逆转失明的潜在并发症.
识别患有SIOH风险的患者对于预防视力丧失至关重要.

研究的目的:

为了研究状网状网 (TM) 高度和SIOH在静脉内德克萨植入后 (OZURDEX) 之间的关联.
为了确定前段光学连贯性断层扫描 (AS-OCT) 是否可以识别预测SIOH的TM特征.
评估TM高度测量在管理SIOH风险中的临床实用性.

主要方法:

一个回顾性病例对照研究,涉及102只眼睛,这些眼睛接受了静脉内德甲植入物.
前段光学连贯断层扫描 (AS-OCT) 用于测量眼睛参数,包括TM高度.
进行了统计分析,包括单变量和多变量后勤回归和ROC曲线分析,以评估TM高度和SIOH之间的关联.

主要成果:

与正常眼内压力组 (784.27 ± 82.33 μm) 相比,SIOH组 (716.13 ± 80.55 μm) 的状眼网 (TM) 高度显著更短 (p < 0.001).
AS-OCT分析显示TM高度特异性的最佳切断值≥802.13μm (96.2%),TM高度<646.75μm的灵敏度为94.70%.
较短的TM身高被确定为与SIOH相关的新风险因素,赔率比为0.990 (p = 0.001).

结论:

通过AS-OCT测量可测的状眼网 (TM) 高度是静脉内德克萨植入后类固醇诱导眼高血压 (SIOH) 的重要预测指标.
患有较短TM高度的患者,特别是低于646.75μm的患者,患有SIOH和随后的视力丧失的风险增加.
在注射类固醇之前,应考虑对TM高度进行AS-OCT评估,以减轻SIOH和不可逆转失明的风险.

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