运动通过其对炎症和氧化应激的作用来减少无脂蛋白E缺陷小鼠的超脂血症诱导的心脏损伤
Zuowei Pei1,2, Jun Ji1, Yanyan Gao1
1Department of Central Laboratory, Central Hospital of Dalian University of Technology, No. 826 Xinan Road, Dalian, 116033, China.
Scientific reports
|June 5, 2023
概括
在高脂血症模型中,运动训练减轻了心脏损伤. 这项对阿波利波蛋白E缺乏的小鼠的研究表明,运动改善了抗氧化剂水平,并减少了纤维化和亡,突出显示了它对心血管疾病的保护作用.
科学领域:
- 心血管疾病研究研究
- 运动生理学 运动生理学
- 分子生物学分子生物学
背景情况:
- 心血管疾病对全球的健康构成重大负担.
- 运动训练是针对各种心血管疾病的既定,基于证据的治疗方法.
- 超脂血是导致心脏损伤的主要危险因素.
研究的目的:
- 在超脂血症引起的心脏损伤的小鼠模型中研究运动训练的心脏保护作用.
- 评估运动对氧化应激,纤维化,亡以及心脏关键分子标记物的影响.
主要方法:
- 缺乏阿波蛋白E (ApoE-/-) 的小鼠在12周内被食正常饮食 (ND) 或高脂肪饮食 (HFD).
- 两组饮食中的小鼠被进一步分为静坐或运动训练 (游泳) 小组.
- 心脏组织病理学,血清生物化学和蛋白质/基因表达 (NOX4,NRF2,SIRT1,TGF-β,HO-1,原III等) 进行了分析.
主要成果:
- 与ND的小鼠相比,在HFD中的小鼠表现出增加的氧化应激,心脏纤维化和亡.
- 与静止型HFD小鼠相比,HFD小鼠 (HFD+E) 的运动训练显著提高了血清抗氧化剂水平 (SIRT1,GSH-Px,SOD).
- 运动训练减轻了病理性心脏变化,减少了氧化应激和纤维化,并减少了HFD小鼠的亡.
结论:
- 运动训练在ApoE-/-小鼠中显示出显著的保护作用,防止高脂血症引起的心脏损伤.
- 运动提高了抗氧化能力,并减轻了与心脏损伤有关的有害分子通路.
- 研究结果支持运动作为一种治疗策略,用于管理与高脂血症相关的心血管并发症.
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