小脑对大脑宽度网络的贡献,用于小鼠的灵活行为
Jessica L Verpeut1, Silke Bergeler2,3,4, Mikhail Kislin2
1Neuroscience Institute, Princeton University, Washington Road, Princeton, NJ, 08544, USA. jverpeut@asu.edu.
Communications biology
|June 5, 2023
概括
小脑后部对于行为灵活性至关重要,包括逆向学习和习惯. 它的影响通过特定的大脑网络延伸,影响非运动功能.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 系统神经科学 系统神经科学
背景情况:
- 小脑在非运动行为中的作用越来越被认可,但具体的神经通路仍然不完全理解.
- 了解小脑电路是解读它对复杂认知功能的贡献的关键.
研究的目的:
- 研究小脑后部在行为灵活性中的作用,特别是逆向学习和习惯.
- 绘制大脑范围的神经网络的地图,通过小脑影响灵活的行为.
主要方法:
- 在小鼠中,化学遗传抑制特定的小脑区域 (小脑叶VI虫子,crus I)
- 使用光片显微镜在清除的整个大脑中结合c-Fos成像的小脑乱.
- 高通量全身运动的自动化分析,用于习惯性评估.
主要成果:
- 抑制六号叶片或I号叶片会影响逆向学习,但不会影响最初的Y-迷宫学习.
- 干扰不同影响了体,手腕,脑下垂体和皮层区域的c-Fos激活.
- 小脑无活化改变了体内的功能相关性,并将新皮质活动划分为子网络.
- 这两种干扰都导致了对开放场环境的行为习惯缺陷.
结论:
- 小脑后部通过不同的二脑和新皮层途径对行为灵活性进行基本控制.
- 小脑电路调节认知灵活性和习惯性的特定方面.
- 这些发现揭示了大脑范围的系统,这些系统是小脑对适应性行为的影响的基础.
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