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Updated: Jul 27, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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针对PI3K异形p110δ的药物的功能影响和分子结合方式

Floyd Hassenrück1,2,3, Maria Farina-Morillas1,2,3, Lars Neumann1,2,3

  • 1University of Cologne, Faculty of Medicine and Cologne University Hospital, Department I of Internal Medicine; Center for Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Cologne, Germany.

Communications biology
|June 5, 2023
PubMed
概括

新的PI3K抑制剂 (PI3Ki) 针对B细胞癌中的p110δ显示出不同的有效性. 一个特定的突变 (I777M) 赋予了对某些PI3Ki的耐药性,影响了更好的癌症治疗药物设计.

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