加拿大的儿科炎症多系统综合征:基于人口的监测和SARS-CoV-2链接的作用
Tala El Tal1, Marie-Paule Morin2, Shaun K Morris3,4,5,6
1Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Pediatric research
|June 5, 2023
概括
与SARS-CoV-2感染相关的儿科炎症多系统综合征 (PIMS) 通常会出现心脏和胃肠道问题. 患有PIMS的儿童,特别是6岁及以上与SARS-CoV-2联系的儿童,面临更高的重症监护室入院风险.
科学领域:
- 儿童传染病 儿童传染病
- 公共卫生监督 公共卫生监督
- 炎症综合征的发生
背景情况:
- 儿科炎症多系统综合征 (PIMS) 是一种与SARS-CoV-2相关的罕见疾病.
- 了解PIMS的临床特征和结果对于及时诊断和管理至关重要.
研究的目的:
- 基于SARS-CoV-2链接,比较住院患有PIMS的儿童的临床特征和结果.
- 为了确定患有PIMS的儿童进入重症监护室 (ICU) 的风险因素.
主要方法:
- 利用了加拿大儿科监测计划 (2020年3月至2021年5月) 的国家监测数据.
- 与具有阳性,阴性和未知SARS-CoV-2联系的患者进行比较.
- 采用多变量修改的波桑回归来确定ICU风险因素.
主要成果:
- 确定了406名患有PIMS的住院儿童;49.8%的患者呈阳性SARS-CoV-2联系.
- 阳性SARS-CoV-2链接的儿童与负性链接的儿童相比,显著增加了心脏参与,胃肠道症状和休克.
- 年龄较大的儿童 (≥6岁) 和具有SARS-CoV-2阳性联系的儿童更有可能需要接受ICU治疗.
结论:
- 大约30%的PIMS住院需要ICU或呼吸/血液动力学支持.
- 阳性SARS-CoV-2链接与更严重的PIMS呈现和增加ICU需求有关.
- 年龄和SARS-CoV-2的联系是PIMS重症监护的关键风险因素.
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