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Updated: Aug 11, 2026

Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System
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在小鼠中非正规的氨基酸整合

Zhetao Zheng1, Qing Xia2

  • 1State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, China.

Methods in molecular biology (Clifton, N.J.)
|June 5, 2023
PubMed
概括

遗传密码的扩展可以创建治疗性蛋白质并抑制引起疾病的突变. 这项研究探讨了它对小鼠遗传性疾病的有效性和安全性.

关键词:
基因准是基因的目标.遗传密码扩展 遗传密码扩展非正规氨基酸的氨基酸.没有意义的突变疾病.翻译机器翻译机器

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.