一个 T T T T T 的
Chenbo Ding1,2, Zhibin Yu1,2, Esen Sefik3,4
1Medical Center on Aging, Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Nature aging
|June 5, 2023
概括
一种新的长非编码RNA,Altre,通过调节调节性T细胞 (Treg) 线粒体功能来维持老年小鼠的肝脏健康. 它的耗尽加速了Treg衰老和肝病的进展,突出了Altre作为治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 衰老研究研究 衰老研究
背景情况:
- 调节性T (Treg) 细胞对于控制与衰老相关的肝脏疾病至关重要.
- 在衰老过程中控制Treg功能的精确分子机制在很大程度上仍未被阐明.
研究的目的:
- 为了确定Treg功能在衰老的肝脏中的分子调节者.
- 研究长非编码RNAAltre在Treg衰老和肝病病原发生中的作用.
主要方法:
- 在小鼠模型中删除Treg特异性基因.
- 线粒体功能测定 (呼吸能力,完整性).
- 反应性氧物种 (ROS) 测量和亡试验.
- 脂质组分析. 脂质组分析.
- 染色体免疫沉和基因表达分析.
主要成果:
- Altre,一个核局部化的 lncRNA,在肝脏Tregs中随着年龄的增长而增加.
- 在老年小鼠中,特异于Treg的Altre缺失导致代谢功能障碍,炎症,纤维化和癌症.
- 其他耗尽损害Treg线粒体功能,增加ROS,并促进亡.
- 阿尔特与阴阳1相互作用,调节线粒体基因表达和Treg适应性.
结论:
- 在老年肝脏中,lncRNA Altre对于维持免疫代谢平衡至关重要.
- 艾尔特维护Treg线粒体功能和通过阴阳1通路的生存.
- 阿尔特代表了与年龄相关的肝脏疾病的有前途的治疗标.
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