综合性视网膜血管测量:范围内的时间与中国2型糖尿病的外周视网膜静脉口径有关
Guohong Zhao1, Xiayu Xu2,3, Xinwen Yu1
1Department of Endocrinology, Shaanxi Province, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, People's Republic of China.
Acta diabetologica
|June 5, 2023
概括
2型糖尿病患者的较低时间范围 (TIR) 与更宽的外周视网膜静脉有关. 这表明早期的糖尿病微血管病变可能首先影响周围血管.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病微血管病是糖尿病的一种并发症,影响小血管.
- 视网膜血管参数作为评估糖尿病微血管病变的关键生物标志物.
- 持续血糖监测 (CGM) 提供了关于血糖控制的宝贵数据,包括时间范围 (TIR).
研究的目的:
- 调查中国2型糖尿病患者用CGM测量TIR与视网膜血管参数之间的关联.
- 为了确定糖分的变化是否影响视网膜血管变化在这个人群中.
主要方法:
- 患有2型糖尿病的成年人通过CGM和视网膜照片同时进行TIR评估.
- 视网膜血管参数使用经过验证的自动化计算机程序量化.
- 用多变量线性回归分析来检查TIR和视网膜血管口径之间的关系.
主要成果:
- 降低TIR四分位数与更广泛的外围动脉静脉和中静脉口径相关.
- 较低的TIR与更广泛的外周静脉显著相关,即使经过对混因素和血糖变化 (GV) 的调整.
- 对于中/中央静脉口径或任何动脉口径,没有观察到类似的关联.
结论:
- 时间范围 (TIR) 与2型糖尿病患者的外周视网膜静脉的不良变化有关.
- 这些发现表明,外周视网膜血管口径可能比中心或中间血管更早受到血糖波动的影响.
- 周围视网膜静脉口径变化可能是糖尿病微血管病变的早期指标.
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