与焦虑相关的全因死亡风险:使用"健康改善网络"数据库进行的回顾性队列研究
Rebecca Russell1, Sonica Minhas1, Joht Singh Chandan2
1Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B152TT, UK.
BMC psychiatry
|June 5, 2023
概括
焦虑稍微增加了死亡风险,但具体风险因焦虑亚型而异. 与压力相关的焦虑表明死亡风险降低,而其他类型的焦虑则增加了风险.
科学领域:
- 流行病学 流行病学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 焦虑是一种常见的疾病,患病率很高.
- 之前关于焦虑和死亡率的研究已经产生了相互矛盾的结果.
- 诸如抑郁症和结焦虑亚型之类的混因素掩盖了真正的死亡风险.
研究的目的:
- 调查诊断出焦虑症与死亡风险之间的关联.
- 在各种焦虑亚型中区分死亡风险.
- 为了解释伴随性抑郁症作为潜在的混因素.
主要方法:
- 使用英国初级保健数据 (2005-2018) 的回顾性队列研究.
- 将345,903名患有焦虑症的患者与691,449名未接触患者进行了匹配.
- 使用考克斯回归来计算死亡率的调整危险比率 (HRs).
主要成果:
- 焦虑与死亡风险略有增加有关 (调整后HR为1.05).
- 死亡风险因焦虑亚型而异.
- 与压力相关的焦虑显示风险降低 (HR:0.88),而"其他"焦虑类型的风险增加 (HR:1.07).
结论:
- 焦虑和死亡率之间存在着复杂的关系.
- 焦虑的诊断与整体死亡率的适度增加有关.
- 特定类型的焦虑是死亡风险的关键决定因素.
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