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在含有l-menthol和carboxypolymethylene的凝配方中的felbinac固体纳米颗粒的皮肤吸收

Reita Kadowaki¹, Fumihiko Ogata¹, Aoi Fushiki¹

¹Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, 577-8502, Osaka, Japan.

Journal of pharmaceutical health care and sciences

|June 5, 2023

概括

这项研究开发了一种新的felbinac (FEL) 纳米粒子凝,用于增强局部输送. 纳米配方显著增加了FEL的皮肤透和吸收,为抗炎治疗提供了改善的局部和全身效果.

科学领域:

药理学药理学是指药理学的学科.
纳米技术纳米技术
皮肤病学皮肤病学

背景情况:

有效的局部配方对于增强皮肤透在皮肤和通过皮肤递送药物中至关重要.
纳米技术为药物输送系统提供先进的解决方案.
费尔比纳克 (FEL) 是一种非类固醇抗炎药物,通常用于局部配方.

研究的目的:

准备和研究一种含有felbinac (FEL) 固体纳米粒子 (FEL-NP凝) 的新型局部配方的局部和全身吸收.
评估纳米技术在增强FEL的皮肤透和吸收方面的有效性.
为了比较开发的FEL-NP凝与常规配方的吸收.

主要方法:

在FEL中,使用珠子研磨来制备固体纳米粒子 (20-200nm).
创建了一个局部凝配方 (FEL-NP凝) 含有FEL纳米粒子,碳酸聚甲,l-menthol,甲基纤维素和2-hydroxypropyl-β-cyclodextrin.
进行了体外和体内研究,以评估FEL释放,通过皮肤透和通过皮肤吸收在老鼠中,比较FEL-NP凝与FEL微粒凝 (FEL-MP凝) 和商业FEL膏.

主要成果:

与FEL-MP凝相比,FEL-NP凝的释放量显著更高.
通过皮肤透和皮肤透吸收FEL显著增加了FEL-NP凝.
对于FEL-NP凝的FEL度-时间曲线 (AUC) 下的面积分别是商业FEL膏和FEL-MP凝的1.52倍和1.38倍.
鼠皮中的FEL含量在FEL-NP凝治疗时显著增加.
发现增强的皮肤透通过能量依赖性内细胞分裂,包括克拉特林介导的内细胞分裂.

结论:

一种含有FEL纳米颗粒的碳聚甲凝成功准备用于局部应用.
细胞内分泌途径在FEL纳米颗粒的增强皮肤透中发挥着关键作用.
应用FEL-NP凝导致FEL的高局部组织度和系统吸收.
这些发现支持使用纳米配方用于局部抗炎治疗,提供本地和全身的好处.

关键词:

药物输送是药物输送的过程.费尔比纳茨 (Felbinac) 是一个在野党人.纳米颗粒是如何形成的皮肤配方皮肤配方一个l-menthol的醇.

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