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周期性为期10天的梅尔法兰剂量用于犬多发性骨髓瘤

Lucy Teddy¹, Skylar R Sylvester¹, Kelly S O'Connor²

¹Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York, USA.

Veterinary and comparative oncology

|June 6, 2023

概括

这项研究评估了10天周期性梅尔法兰化疗方案,用于治疗犬多发性骨髓瘤 (MM). 该方案显示了最小的不良事件,但与其他治疗相比,反应率较低,这表明狗MM的耐受性和疗效之间存在潜在的权衡.

科学领域:

兽医瘤学兽医瘤学
内部医学内部医学
药理学药理学是指药理学的学科.

背景情况:

狗多发性骨髓瘤 (MM) 管理通常涉及梅尔法兰化疗.
一个为期10天的循环梅尔法兰剂量方案已被使用,但在文献中以前没有记录.
了解治疗结果和不良事件对于优化犬类MM护理至关重要.

研究的目的:

描述MM.狗的10天周期性梅尔法兰化疗方案的结果和不良事件.
为了比较本协议与其他报告的化疗方案的疗效和安全性.
为了确定与这种方案治疗的狗的整体存活率相关的因素.

主要方法:

在康奈尔大学动物医院追溯17只被诊断患有MM的狗的病例系列,并用10天的循环梅尔法兰协议治疗.
数据收集包括临床症状,诊断结果 (高血球蛋白血症,单克隆性血病,骨髓血细胞瘤),治疗反应 (完全反应[CR],部分反应[PR]),生存时间和不良事件.
使用多变量分析来确定总生存期的预后因素.

主要成果:

惰是最常见的症状;临床症状的平均持续时间为53天.
大多数狗中都存在高血球血和单克隆性血病;骨髓血细胞瘤是普遍存在的.
观察到的整体响应率为76% (59%的CR,18%的PR). 平均整体生存时间为512天.
视网膜脱落和实现CR/PR与改善的生存率有关.
副作用是最小的,腹是最常见的 (n=6).

结论:

10天周期性梅尔法兰协议在MM的狗中耐受良好,比其他报告的协议更少出现不良事件.
虽然耐受性更好,但该方案的响应率较低,可能是由于剂量强度降低.
可能需要进一步的研究来平衡基于梅尔法兰的化学疗法的耐受性和疗效,以治疗犬多发性骨髓瘤.

关键词:

狗类犬类动物狗类犬类化疗化疗是一种化学疗法.狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗梅尔法兰 (Melphalan) 是一个有趣的词.多发性骨髓瘤是多发性骨髓瘤的一种.血细胞的血细胞是什么

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