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在强迫症障碍中对肠道微生物组的纵向研究
Long Long Chen1, Afrouz Abbaspour2, Kristina Aspvall1
1Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, & Stockholm Health Care Services, Stockholm, Sweden.
与健康对照组相比,强迫症 (OCD) 患者的肠道微生物组在多样性或功能方面没有显著差异. 暴露和反应预防 (ERP) 疗法的治疗没有改变强迫症患者的肠道微生物组合.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 强迫症 (OCD) 与环境限制和重复行为有关.
- 这些行为可能会影响肠道微生物群,促使人们对其在强迫症中的作用进行调查.
- 认知行为疗法,特别是暴露和反应预防 (ERP),是强迫症的关键治疗方法.
研究的目的:
- 在ERP治疗之前和之后调查强迫症患者肠道微生物组的纵向变化.
- 为了比较强迫症患者和健康对照 (HC) 之间的肠道微生物组组成和功能.
主要方法:
- 64名参与者 (32名强迫症患者,32名健康患者) 接受了精神病学评估和营养评估.
- 便样本从强迫症患者的ERP前和ERP后 (1个月) 和HCs收集.
- 微生物组全基因组测序用于分类学和功能分析.
主要成果:
- 在基线,强迫症患者的纤维消耗量明显低于HC患者.
- 在强迫症患者和HC之间,或在ERP前后的强迫症患者中,没有发现肠道微生物群多样性 (α和β) 或物种级分类组合的显著差异.
- 在56个神经活性肠-大脑模块的表达中,在组之间或随着时间的推移中没有观察到显著的差异.
结论:
- 强迫症患者的肠道微生物群的多样性,组成和功能概况与HCs没有显著差异.
- 在强迫症患者中,肠道微生物组随着时间的推移保持稳定,即使经过ERP治疗.
- 这些发现表明肠道微生物组可能不是受强迫症行为变化影响的主要因素.
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