一项复杂的干预措施,以防止与药物相关的住院病例
Antje Neubert1, Irmgard Toni1, Jochem König2
1Department of Pediatric and Adolescent Medicine, University Hospital Erlangen
Deutsches Arzteblatt international
|June 6, 2023
概括
儿科药物治疗的质量保证措施显示了减少住院治疗的趋势,但没有达到统计学意义. 在门诊儿科环境中,PaedPharm的干预被广泛接受.
科学领域:
- 儿科药物治疗药物治疗.
- 药物安全和质量保证的药物安全和质量保证.
- 医疗服务研究 医疗服务研究
背景情况:
- 儿童经常接受非标签药物治疗,增加了他们在药物治疗中的风险.
- 与药物相关的住院治疗是儿科和青少年医学的一个重大问题.
研究的目的:
- 实施和评估PaedPharm针对儿科药物治疗的质量保证措施.
- 减少儿童和青少年中与药物相关的住院治疗.
主要方法:
- 一个集群随机试验 (DRKS 00013924) 涉及12个地区和152名从业者.
- PaedPharm包括一个数字药物信息系统 (PaedAMIS),质量圈 (PaedZirk) 和一个不良药物事件 (ADE) 报告系统 (PaedReport).
- 主要终点是与ADE相关的住院病例;过程评估包括用户接受度和实践相关性.
主要成果:
- 分析了41,829例住院患者的入院病例;5,101例来自参与的医生.
- 与ADE相关的住院病例从4.1% (对照组) 降至3.1% (干预组),尽管在统计学上不显著 (p = 0.33).
- PaedAMIS的用户接受度中等,而PaedZirk的用户接受度很高.
结论:
- PaedPharm的干预与与药物相关的住院病例的非显著减少有关.
- 在门诊儿科和青少年医学环境中观察到PaedPharm干预的广泛接受.
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