了解 (-) - ∆ 体转移的机制和程度
Aditya R Kumar1, Emily D Sheikh2, Joshua W Monson2
1Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Clinical pharmacology and therapeutics
|June 6, 2023
概括
在怀孕期间使用大麻会使胎儿暴露在THC中. THC在胎盘中被积极运输,而其代谢物被被动扩散,导致胎儿THC水平降低.
科学领域:
- 药理学 药理学是指药理学的学科.
- 产科 产科 产科 产科 产科
- 毒理学 毒理学 毒理学
背景情况:
- 怀孕期间使用大麻会带来风险,因为胎儿会接触THC及其代谢物.
- 与母亲水平相比,观察到较低的胎儿血THC度表明有活跃的运输机制.
- 了解胎盘转移对于评估与母亲大麻使用相关的胎儿风险至关重要.
研究的目的:
- 研究 (-) - ∆9 - 四大麻素 (THC) 和其代谢产物的胎盘运输机制.
- 为了确定THC及其代谢物是否通过胎盘输送器流出.
- 在人类胎盘模型中量化THC及其代谢物的胎盘转移.
主要方法:
- 利用一个双透术语的人类胎盘模型.
- 将THC (5μM) 和其代谢物 (11-OH-THC,COOH-THC) 输入母亲的血液循环.
- 使用清除指数和P-glycoprotein (P-gp) 和乳腺癌抗性蛋白 (BCRP) 抑制剂评估胎盘运输.
主要成果:
- THC的母胎清除明显低于胎胎清除,这表明有活跃的排泄物.
- 这种THC流量并未被valspodar抑制,这是一个P-gp/BCRP对手.
- THC代谢物 (11-OH-THC,COOH-THC) 在双向清除中没有显著差异,这表明被动扩散.
结论:
- 在胎盘中,THC通过独立于P-gp/BCRP的运输体 (运输体) 进行活跃的运输.
- 似乎THC代谢物通过被动扩散穿过胎盘.
- 这些发现支持体内THC的胎儿与母亲稳定状态血度比较低.
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