使用带血作为儿科包装红细胞的来源:加工和质量控制
Mariane Aparecida Risso1, Elenice Deffune2, Ângela Cristina Malheiros Luzo1,3
1Transfusion Medicine Service, Stem Cell Processing Laboratory, Umbilical Cord Blood Bank, Hematology Hemotherapy Center, University of Campinas (UNICAMP), Campinas, Brazil.
Vox sanguinis
|June 6, 2023
概括
用手动或自动化方法,可以将带血加工成红细胞 (RBC) 用于儿科输血. 这些带红细胞符合与成年红细胞可比的质量标准,尽管生物化学方面需要进一步研究.
科学领域:
- 血液银行和输血医疗服务
- 新生儿和儿科血液学
背景情况:
- 带血 (UCB) 是红细胞 (RBC) 恢复的公认来源.
- 目前用于新生儿和儿科的输血实践通常使用成年红血细胞 (A-RBC) 分割.
研究的目的:
- 通过两种不同的方法处理的带红细胞 (U-RBC) 的质量控制参数与A-RBC进行比较.
- 评估U-RBCs对于儿科输血目的的适用性.
主要方法:
- 24个UCB单位使用传统/手动 (P1) 或自动化 (P2) 方法进行处理.
- 经过处理的U-RBC和A-RBC被储存了14天,并间隔分析了血液学,生化学,溶血学和微生物学的参数.
- 在剩余的U-RBC血中量化了细胞因子和生长因子.
主要成果:
- 手动和自动处理都产生了U-RBCs,其体积和血红素水平与A-RBCs相似.
- 血液学和生物化学参数在储存期间显示了类似的趋势,U-RBC和A-RBC之间的值差异明显.
- 与A-RBC血相比,残留的U-RBC血表现出更高度的促炎细胞因子和生长因子.
结论:
- 使用手动和自动化协议,可以有效地将带血加工成红细胞.
- 经过加工的U-RBC满足了A-RBC的既定质量参数.
- 建议对生化差异进行进一步的研究,以优化输血的U-RBC质量.
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