母亲的饮食和肠道微生物组合调节了生命早期的免疫发育
Erica T Grant1,2, Marie Boudaud1, Arnaud Muller3,4
1Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
EMBO molecular medicine
|June 6, 2023
概括
母亲的纤维摄入量塑造后代的肠道微生物和免疫发育. 缺乏纤维的母亲延迟了Akkermansia muciniphila的殖民化,影响了幼的免疫路径.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
背景情况:
- 早期免疫系统的发展对于微生物的耐受性至关重要.
- 母亲饮食对后代免疫成熟和肠道微生物群的影响尚未完全理解.
研究的目的:
- 研究母亲的饮食和微生物组成如何影响后代免疫系统的发展.
- 了解Akkermansia muciniphila在生命早期免疫成熟中的作用.
主要方法:
- 没有细菌的小鼠被一个14个菌株的微生物联盟所殖民.
- 给小鼠食富含纤维或无纤维的饮食,并监测后代的发育.
- 分析了后代肠道微生物组和免疫反应 (结肠转录,细胞因子表达,免疫细胞子集).
主要成果:
- 来自缺乏纤维的水的幼显示了延迟的Akkermansia muciniphila殖民.
- 纤维剥夺导致结肠防御反应通路的增加以及幼犬的Interleukin-22 (Il22) 表达.
- 删除A. muciniphila,即使在富含纤维的饮食中,也减少了特定的先天性和适应性免疫细胞群.
结论:
- 孕产妇的食纤维显著影响了幼儿的肠道微生物组合和后代的免疫系统发育.
- 在关键的产后时期,Akkermansia muciniphila在调节免疫系统方面发挥着作用.
- 早期的微生物殖民和母亲的饮食是免疫耐受性和防御的关键决定因素.
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