Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Anatomy of the Intestines01:23

Anatomy of the Intestines

72.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.6K
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

532
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
532
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

333
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
333
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K
Small Intestine01:15

Small Intestine

1.1K
The small intestine is primarily responsible for digestion and nutrient absorption. It spans from the pyloric sphincter to the ileocecal valve and connects to the large intestine.
The small intestine is divided into three main sections - the duodenum, jejunum, and ileum. The duodenum, approximately 25 cm long, is nearest the stomach. It acts as a 'mixing bowl,' where chyme (partially digested food) blends with digestive enzymes from the pancreas and liver. The duodenum's unique...
1.1K
Intestinal Phase of Digestion01:29

Intestinal Phase of Digestion

5.3K
The intestinal phase of digestion is the third and final stage of the digestive process, occurring after the cephalic and gastric phases. It begins when chyme, a partially digested mixture of food and digestive enzymes, enters the small intestine from the stomach. This phase is crucial for nutrient absorption and involves complex hormonal and enzymatic interactions.
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
5.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Photoprotective Potential of a Yeast/Rice Fermentation Filtrate and Sialic Acid in Mitigating UVA-Induced Oxidative Stress and Mitochondrial Dysfunction in Skin Fibroblasts.

Molecules (Basel, Switzerland)·2026
Same author

Enzymatic Synergy-Driven Biotransformation Generates a Postbiotic-Rich Functional Matrix That Reprograms Gut Microbiota Metabolic Pathways Under Stress Conditions.

International journal of molecular sciences·2026
Same author

<i>Fusobacterium nucleatum</i> Enhances Intestinal Adaptation of <i>Vibrio cholerae</i> via Interspecies Biofilm Formation.

Microorganisms·2026
Same author

In Vitro Anti-Aging Effects of Yeast/Rice Fermentation Filtrate Combined with Sialic Acid in Cosmetic Applications.

Antioxidants (Basel, Switzerland)·2025
Same author

Sialic Acid-Loaded Nanoliposomes with Enhanced Stability and Transdermal Delivery for Synergistic Anti-Aging, Skin Brightening, and Barrier Repair.

Pharmaceutics·2025
Same author

In vivo systematic analysis of microbiota-prebiotic crosstalk reveals a synbiotic that effectively ameliorates DSS-induced colitis in mice.

Gut microbes·2025

相关实验视频

Updated: Jul 27, 2025

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
05:27

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

4.4K

肠道土著的土著人

Rong Li1, Sheng Xu2, Bei Li1

  • 1Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan 430074, Hubei, China. zhiliu@hust.edu.cn.

Food & function
|June 6, 2023
PubMed
概括
此摘要是机器生成的。

耐火性便秘涉及肠道微生物群失调. 在患者便中发现的一种特定菌株Ruminococcus gnavus有效地改善了小鼠的便秘症状,这表明了潜在的微生物治疗方法.

更多相关视频

Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut
09:13

Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut

Published on: January 31, 2025

507
Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
10:51

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

22.5K

相关实验视频

Last Updated: Jul 27, 2025

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
05:27

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

4.4K
Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut
09:13

Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut

Published on: January 31, 2025

507
Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
10:51

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

22.5K

科学领域:

  • 微生物学 微生物学
  • 胃肠病学 胃肠病学
  • 医学科学 医学科学 医学科学

背景情况:

  • 耐火性便秘是一种严重的形式,其原因不明,并对患者的身体和心理健康产生重大影响.
  • 便秘与肠道微生物群失调有关,在健康个体和患者之间观察到明显的差异.
  • 越来越多的证据表明,肠道微生物组在便秘的病理生理学中起着至关重要的作用.

研究的目的:

  • 研究耐火性便秘患者新鲜便和累积便之间的肠道微生物组合的差异.
  • 评估特定肠道微生物的治疗潜力,特别是本土菌株,用于治疗耐火性便秘.
  • 探索肠道微生物影响肠道功能和便秘行为的机制.

主要方法:

  • 从耐火性便秘患者的新鲜和累积便样本中分析肠道微生物群组成.
  • 建立了洛佩拉胺诱导的便秘小鼠模型,以评估便微生物群移植的影响.
  • 已识别的本土菌株Ruminococcus gnavus口服给便秘的小鼠.

主要成果:

  • 在耐火性便秘患者的新鲜便和累积便之间发现了肠道微生物组成的显著差异.
  • 来自患者的新鲜便减轻了小鼠的便秘症状,而老便加剧了它们,反映了健康的供体便的影响.
  • 口服Ruminococcus gnavus有效改善了小鼠的便秘和与压力相关的行为,这表明它具有治疗作用.

结论:

  • 使用像Ruminococcus gnavus这样的土著菌株进行肠道微生物干预,对治疗耐火性便秘有希望.
  • 鲁米诺科克斯 (Ruminococcus gnavus) 可能通过调节muc2,c-kit和sert等基因以及控制体静止素和运动素的产生来发挥其有益作用.
  • 向肠道微生物群代表了严重便秘患者的潜在替代治疗策略.