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对cT1-4 N0M0头部和部状癌的选择性部剖析

Aman M Patel¹, Sudeepti Vedula¹, Afash Haleem¹

¹Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

|June 6, 2023

概括

选择性部剖析 (END) 对头癌 (HNVC) 患者没有显著的生存优势. 这项研究发现,与HNVC.的观察相比,END对生存没有明显的益处.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
头部和部手术头部和部手术

背景情况:

头椎瘤 (HNVC) 是状细胞癌的一种罕见亚型.
在临床上阴性节点 (cN0) HNVC 部的管理仍然存在争议.
选择性部剖析 (END) 是在cN0 HNVC.中管理部的一种手术选择.

研究的目的:

研究选择性部剖析 (END) 与临床阶段T1-4 N0M0头椎瘤 (HNVC) 患者的部观察相比的生存益处.

主要方法:

使用国家癌症数据库 (2006-2017) 的数据进行了回顾性队列研究.
包括手术切除cT1-4 N0M0 HNVC.的患者.
统计分析包括线性,二元物流,卡普兰-梅尔和考克斯比例危险回归模型.

主要成果:

在1015名患者中,223人 (22.0%) 接受了END. 5年整体存活率 (OS) 为71.3%的END,而没有END的70.6% (p=0.661).
END并没有显著降低5年死亡风险 (调整后的风险比:1.25;95% CI:0.91-1.71;p=0.172).
在各种子组分析中,没有观察到END有显著的生存益处.

结论:

选择性部剖析 (END) 在头癌 (HNVC) 中没有显著的生存益处.
对cN0 HNVC患者来说,部观察似乎是END的可行替代方案.
可能需要进一步的研究来完善cN0 HNVC的治疗指南.

关键词:

国家癌症数据库.头部和部癌症头部和部癌症部解剖部解剖部解剖隐秘的神秘活动的癌瘤是的癌症.

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