在自闭症患者中,重复注射鼻内催产素是否会影响神经对表情面孔敏感度的降低? 一个随机对照试验
Matthijs Moerkerke1,2, Nicky Daniels2,3, Stephanie Van der Donck1,2
1Center for Developmental Psychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium.
概括
在患有自闭症谱系障碍 (ASD) 的儿童中,重复的催产素 (OT) 喷雾并没有改善面部处理神经敏感性. 相反,OT似乎抑制了安慰剂组中观察到的学习效应,这表明它有压力调节作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 自闭症谱系障碍 (ASD) 涉及到社会沟通方面的挑战.
- 面部信息处理是社会互动的关键.
- 催产素 (OT) 正在探索改善自闭症患者的社会困难.
研究的目的:
- 研究反复的鼻内催产素 (OT) 对ASD儿童面部表情神经敏感性的影响.
- 使用频率标记电脑图 (EEG) 来测量神经反应.
- 比较ASD儿童与神经类型 (NT) 儿童的效应.
主要方法:
- 随机,双盲,安慰剂控制的药物神经成像试验.
- 服用OT (12IU每天两次) 或安慰剂4周.
- 在基线,治疗后和随访时使用EEG评估神经敏感性.
主要成果:
- 与NT儿童相比,患有ASD的儿童对表情面孔的神经敏感性降低.
- 而安慰剂组在治疗后显示神经敏感度增加,这表明学习.
- 在OT组中,神经敏感度没有变化,这表明学习效果减弱.
结论:
- 频率标记EEG有效地测量了ASD中神经敏感度的降低.
- 重复的OT给药减弱了神经敏感性的隐性学习效应.
- OT的影响可能与社会压力调节有关,而不是直接增强社会突出.
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