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金属纳米颗粒的肠道毒性:银纳米颗粒破坏了肠道免疫微环境

Quanzhong Ren^1,2, Juan Ma^2,3, Xiaobo Li¹

¹Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China.

ACS applied materials & interfaces

|June 6, 2023

概括

口服接触银纳米粒子 (Ag NPs) 会导致严重的肠损伤,通过影响树突细胞 (DCs) 和T细胞分化,改变免疫微环境. 这凸显了工程金属NP的潜在健康风险.

科学领域:

免疫学免疫学免疫学
纳米技术纳米技术
毒理学毒理学毒理学

背景情况:

工程金属纳米粒子 (NP) 的毒性已被广泛研究,但它们在口服暴露后对肠道免疫微环境的影响尚不清楚.
了解这些影响对于评估与NP相关的健康风险至关重要.
银纳米粒子 (AgNP) 是常见的工程NP,具有潜在的口服暴露路径.

研究的目的:

调查口服暴露于工程金属NP对肠道系统的长期影响.
为了识别导致严重肠道损伤的特定NP.
阐明Ag NP诱导的肠道免疫失调背后的机制.

主要方法:

在动物模型中口服代表性工程金属NP.
肠道组织结构和粘膜层厚度的组织学分析.
流细胞计和体外试验测试以评估树突细胞 (DC) 激活,细胞亡和T细胞分化.
分析肠道微生物群的组成.

主要成果:

口服Ag NP暴露导致严重的肠损伤,包括上皮结构破坏和粘膜厚度降低.
由于粘膜厚度降低,Ag NPs被DCs更容易细胞化.
AgNP与DC直接相互作用,导致异常激活,反应性氧物种生成和亡.
AgNP暴露改变了DC群体 (减少了CD103+CD11b+DCs) 和倾斜的T细胞对Th17激活的反应,同时抑制了调节性T细胞.

结论:

AgNP对肠表皮和免疫微环境造成重大损害.
Ag NPs和DCs之间的相互作用会破坏免疫平衡,导致炎症.
这些发现提供了关键的见解AgNP通过口服暴露对健康的风险,并为未来的安全评估提供信息.

关键词:

树突细胞的树突细胞.工程制造的纳米粒子.免疫微观环境免疫微环境我们的肠道是肠道.口服暴露口服暴露的时间

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