基底质病变可能是眼光盘特征特征的危险因素:日本基于人口的队列研究
Hideki Fukuoka1,2, Yukiko Nishita3, Chikako Tange2
1Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
BMJ open ophthalmology
|June 6, 2023
概括
视神经垂直杯与圆盘比率 (VCDR) 的升高与日本老年人基底关节病变有关. 这表明神经系统与眼风险有潜在的联系,需要进一步调查.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 调查眼风险因素中的潜在未识别的神经元件.
- 检查视神经垂直杯与盘的比率 (VCDR),身体和眼睛的参数,以及大脑病变之间的关系.
- 专注于中年和年长的日本人.
研究的目的:
- 探索VCDR与大脑病变 (包括基底脉梗塞) 之间的关联.
- 为了确定眼睛和神经学参数是否在老龄化人口中联系在一起.
- 为了识别潜在的新型风险因素,对玻璃眼.
主要方法:
- 来自国家长寿科学研究所的2239名日本受试者 (40岁以上) 的横截面研究-老龄化的纵向研究.
- 评估了4327个眼睛和2239个头部的MRI.
- 应用多变量混合模型和趋势分析.
主要成果:
- 在VCDR和大多数大脑病变之间没有发现显著的关系.
- 在高度的基底脉梗塞病变 (p=0.0193) 和高眼内压 (p<0.0001) 时,VCDR显著增加.
- 在VCDR和基底关节病变的严重程度之间观察到显著的正线性趋势 (p趋势=0.0096).
结论:
- 升高的VCDR需要在患有更高度基底腺病变的个体中引起注意.
- 研究结果表明,基底腺病变与VCDR之间存在潜在的联系.
- 需要进一步的研究来证实这些结果及其临床影响.
相关概念视频
01:25Glaucoma: Overview
633
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
633
01:27Open Angle Glaucoma: Treatment
497
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
497