肉毒毒素注射和2型甲状腺整形术的比较,用于诱导器性失声症
Tetsuji Sanuki1, Naoki Takemoto1
1Department of Otolaryngology-Head & Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
The Laryngoscope
|June 6, 2023
概括
2型甲状腺整形 (TP2) 为辅助器性失声症 (AdSD) 提供了一个有希望的外科替代方案,与肉毒素 (BTX) 注射相比,它可能提供更持久的声音改善.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经学 神经学
- 语音和语言病理学 语言病理学
背景情况:
- 诱导器性失声症 (AdSD) 通常通过注射肉毒素 (BTX) 进入喉肌肉来管理.
- BTX注射提供暂时的缓解,需要重复治疗,以保持声音质量.
- 为了更稳定和长期的ADSD管理,正在探索手术干预.
研究的目的:
- 为了比较使用TITANBRIDGE®与BTX注射用于AdSD的2型甲状腺整形术 (TP2) 的长期疗效.
- 在接受TP2和BTX的患者中,使用语音障碍指数 (VHI) -10评估语音质量改善.
主要方法:
- 在2018年8月至2022年2月期间,73名AdSD患者的队列被提供BTX注射或TP2注射.
- 语音障碍指数 (VHI) -10分数在治疗前和多次随访间隔评估.
- 对BTX患者进行了12周的随访,而对TP2患者进行了52周的随访.
主要成果:
- 注射BTX显著改善了短期VHI-10得分,但在12周后得分恢复到基线.
- 在手术后52周,TP2治疗导致显著和持续的VHI-10得分改善.
- 在12周后,TP2和BTX组之间观察到语音质量的显著差异.
结论:
- 2型甲状腺整形 (TP2) 显示出作为ADSD的持久性外科治疗选择的潜力.
- 与传统的BTX注射相比,TP2可能会提供更稳定,更持久的语音质量改善.
- 对TP2进行进一步的研究是有必要的,以确定其在AdSD的长期管理中的作用.
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