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化学治疗中患有急性淋巴细胞白血病的儿科患者的营养状况:试点长度研究
Ibrahim Kandemir1, Sema Anak2, Serap Karaman3
1Department of Pediatrics, Faculty of Medicine, Biruni University.
Journal of pediatric hematology/oncology
|June 6, 2023
概括
患有急性淋巴细胞白血病 (ALL) 的儿童在化疗期间面临营养不良的风险,特别是年轻患者. 营养状况需要在整个治疗过程中密切监测,以管理体重变化和潜在的肥胖症.
科学领域:
- 儿科瘤学 儿科瘤学
- 临床营养学 临床营养学
- 血液学 血液学 血液学
背景情况:
- 在接受急性淋巴细胞白血病 (ALL) 化疗的儿童中,营养状况至关重要.
- 营养不良与儿科患者的癌症治疗一起构成重大挑战.
研究的目的:
- 在化疗期间调查ALL儿童的营养状况.
- 评估不同治疗阶段的人类测量数据和关键营养水平.
主要方法:
- 在伊斯坦布尔的五个中心对17名患有ALL的儿童 (1-16岁) 进行了纵向研究.
- 在诊断,诱导后和维持前的化疗中评估了人体测量,血清前白蛋白,维生素B12和叶酸水平.
主要成果:
- 诱导化疗后观察到显著的体重减轻和血清前白蛋白,体重与身高和体重与年龄的比率下降.
- 60个月以下的儿童表现出较低的前白蛋白水平,低于参考值.
- 在维护之前,体重和体重与年龄相比显著增加,表明潜在的肥胖风险;血清叶酸水平上升,而维生素B12保持稳定.
结论:
- 营养不良是ALL诱导化疗结束时的风险,需要密切监测营养,特别是在5岁以下的儿童中.
- 体重增加和潜在的肥胖风险出现在维持阶段之前.
- 需要进一步的研究,以全面评估整个儿童时期的营养状况.
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