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基于双酸盐的扩展协调聚合物的设计,作为乳腺癌诱导的骨解质转移和其他骨疗法的骨向药输送系统

Lesly Carmona-Sarabia^1,2, Gabriel Quiñones Vélez^1,2, Andrea M Escalera-Joy^1,2

¹Department of Chemistry, University of Puerto Rico, Río Piedras, San Juan, Puerto Rico 00931, United States.

Inorganic chemistry

|June 6, 2023

概括

新的双酸盐基协调聚合物 (BPCP) 显示出治疗骨转移的前景. 纳米-Ca@BBPA显示出高的骨亲和力,有效地将5-甲 (5-FU) 传递给癌细胞,同时不影响健康细胞.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

烯1,4-bis(双酸) (BBPA) 是一个双酸盐 (BP) 的类似物.
基于双酸盐的协调聚合物 (BPCPs) 是使用BBPA和生物活性金属合成的.
针对骨转移的现有药物输送系统在有效性和特异性方面面临挑战.

研究的目的:

开发用于向骨转移的药物输送的新型BPCP.
研究BBPA-Ca协调聚合物的特性,包括它们封装药物的能力.
评估纳米-Ca@BBPA作为乳腺癌诱导骨解转移的药物输送系统的疗效.

主要方法:

合成BBPA-金属协调聚合物的四个不同的晶体相 (BBPA-Ca形式I和II,BBPA-Zn,BBPA-Mg).
在BBPA-Ca形式I和II的通道内封装5-甲 (5-FU).
使用相逆温度方法,减少BBPA-Ca形式II的颗粒大小,形成纳米Ca@BBPA.
实验室溶解研究,酸结合测定,药物加载/释放研究和细胞活力测定.

主要成果:

BBPA-Ca形式I和II具有适用于5-FU封装的道.
BBPA-Ca形式II表现出pH值依赖的稳定性,在酸性条件下崩.
与BBPA和商业双酸盐相比,Nano-Ca@BBPA显示出明显更高的酸结合亲和力.
药物加载的纳米-Ca@BBPA有效地增加了三阴性乳腺癌细胞的细胞毒性,对正常骨质母细胞的影响最小.

结论:

纳米-Ca@BBPA是一种有前途的药物输送系统,对骨组织具有很高的亲和力.
这种材料可以有效地将5-FU输送到向癌细胞,为骨解转移提供潜在的治疗方法.
开发的纳米-Ca@BBPA系统显示出高的特异性和有效性,为临床应用提供了进一步的研究.

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