从海星中获得的星素
Le Thi Vien1, Tran Thi Hong Hanh1, Tran Hong Quang1
1Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Caugiay, Hanoi 10072, Vietnam.
Journal of Asian natural products research
|June 6, 2023
概括
海星Protoreaster nodosus产生了五种星素,包括一个新的化合物,protonodososide. 这些化合物被测试了它们对抗各种人类癌症细胞系的潜力.
科学领域:
- 海洋天然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 海星是生物活性化合物的丰富来源.
- 星素是一种具有多种生物活性的自然产品类.
研究的目的:
- 从Protoreaster nodosus中分离和表征星素.
- 评估与人类癌症细胞系对隔离化合物的细胞毒性作用.
主要方法:
- 从海星中提取甲醇.
- 染色学分离技术. 染色学分离技术.
- 1D,2DNMR和HR ESI QTOF质谱仪用于结构阐明.
- 对HepG2,KB,MCF7,LNCaP和SK-Mel2细胞系进行细胞毒性测定.
主要成果:
- 隔离了五种星素,其中一种被确定为一种新化合物,即protonodososide.
- 通过光谱分析证实了所有分离化合物的结构.
- 对所有化合物的细胞毒性数据与测试的癌症细胞系相比,得到了数据.
结论:
- 原生结体是新型星素的来源.
- 隔离的阿斯特罗萨尼因对人类癌症细胞系具有不同程度的细胞毒性,需要进一步调查.
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