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皮肤和肠道微生物与固体器官移植接受者状细胞癌的关联

Megan V Ha^1,2, Thomas S McCormick³, Iman Salem³

¹Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH, USA. mvh22@case.edu.

Archives of dermatological research

|June 6, 2023

概括

有史以来状细胞癌 (SCC) 的固体器官移植接受者表现出明显的皮肤和肠道微生物组特征. 这表明微生物标记物可以帮助预测这些患者的SCC风险.

科学领域:

微生物学微生物学
皮肤病学皮肤病学
移植免疫学移植免疫学

背景情况:

固体器官移植接受者 (SOTRs) 患状细胞癌 (SCC) 的风险更高.
微生物失生症与移植结果有关.
了解具有和没有SCC史的SOTRs中的微生物群差异至关重要.

研究的目的:

为了确定皮肤和肠道微生物组之间的差异,在SOTRs和没有SCC的历史.
探索微生物失生症在SOTRs中SCC发展中的潜在作用.

主要方法:

病例控制研究涉及20名SOTR (10名有SCC病史,10名没有).
收集和分析非损伤性皮肤和便样本.
下一代测序用于微生物组分析,使用ANOVA和Tukey测试进行统计比较.

主要成果:

具有SCC史的SOTR在皮肤上表现出增加的细菌和减少的真菌多样性.
相反,具有SCC史的SOTR显示肠道中的细菌和真菌多样性减少.
在两个队列之间观察到微生物多样性指数的显著差异 (p < 0.05).

结论:

独特的皮肤和肠道微生物群落与SOTRs的SCC史有关.
微生物标志物显示出在实体器官移植受体中SCC风险预后的潜力.
需要进一步的研究来阐明微生物组变化与SOTRs中SCC发展之间的因果关系.

关键词:

细菌组是细菌组中的一个.微生物组是一个微生物组.这就是我的mycobiome.实体器官移植实体器官移植状细胞癌瘤是一种状细胞癌.移植移植移植移植

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