开发SARS-CoV-2感染后急性后果的定义
Tanayott Thaweethai1,2, Sarah E Jolley3, Elizabeth W Karlson4
1Massachusetts General Hospital, Boston.
JAMA
|June 6, 2023
概括
后急性SARS-CoV-2感染 (PASC) 或长期COVID影响了许多人,发现了37种症状. 一项前性研究根据症状定义了PASC,在感染后六个月,10%的测试结果呈阳性.
科学领域:
- 传染性疾病
- 公共卫生
- 临床医学
背景情况:
- 在SARS-CoV-2感染后持续出现的症状,称为SARS-CoV-2感染的后急性后果 (PASC) 或长期COVID,需要标准化表征.
- 分析来自不同群体的前性和统一收集的数据对于理解PASC至关重要.
研究的目的:
- 使用自我报告的症状来确定PASC的定义.
- 确定不同人口群体,疫苗接种情况和感染史中PASC的发生频率.
主要方法:
- 一项前性观察队列研究,涉及美国和波多黎各85个地区的9,764名成年人.
- 参与者在急性SARS-CoV-2感染或诊断后至少六个月完成了症状调查.
- 数据收集包括基于人口,志愿者和便利抽样方法.
主要成果:
- 受感染者与未受感染者的37个症状的调整几率为1. 5或更高.
- 导致PASC的主要症状包括运动后的不适,疲劳,脑雾和胃肠道问题.
- 在2021年12月1日之后感染的参与者中,10%的参与者在六个月后被确定为PASC.
结论:
- 根据大量前性队列的症状数据,制定了PASC的初步定义.
- 为了创建可操作的PASC定义,需要进一步细化并包含额外的临床特征.
- 这项研究为未来的PASC研究和临床定义提供了基础框架.
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