P2Y2受体通过抑制ENaC来降低血压
Antonio G Soares1,2, Jorge Contreras1, Elena Mironova1
1Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
JCI insight
|June 6, 2023
概括
刺激细胞中的P2Y2受体 (P2ry2) 通过调节分泌,降低血压. 这项研究证实了脏的存在.
科学领域:
- 生理学 生理学 生理学
- 腎臟病學 (nephrology) 是一種醫學.
- 药理学 药理学是指药理学的学科.
背景情况:
- 与Gq结合的P2Y2受体 (P2ry2) 影响血压,涉及全球淘汰和血管/脏机制.
- 脏P2ry2在血压调节中的特定作用及其分子机制尚不清楚.
研究的目的:
- 调查脏P2ry2对于血压调节的必要性.
- 为了确定主细胞中的Gq依赖信号是否足以调节上皮质通道 (ENaC),分泌和血压.
主要方法:
- 使用了主要的细胞特异性P2ry2-Knockout小鼠和子期对照.
- 服用P2ry2激动剂,并利用药物遗传学激活主要细胞中的Gq信号.
- 在高血压的脱氧皮质酸盐-盐 (DOCA-盐) 模型中测量了表皮质道 (ENaC) 活性,分泌和血压.
主要成果:
- 在对照小鼠的管中,P2ry2激活降低了ENaC活性,但在主要细胞特异性的P2ry2-Knockout小鼠中没有.
- 主要细胞中P2ry2的删除取消了P2ry2诱导的尿和损害了负载的分泌.
- 主要细胞特异性P2ry2淘汰阻止了DOCA盐高血压小鼠中P2ry2刺激的降血压效应.
- 主要细胞中的药物遗传Gq激活模仿了这些效应,降低了ENaC活性和降低了血压.
结论:
- 脏在调解P2ry2激活的降血压效果方面发挥着至关重要的作用.
- 主要细胞中的P2ry2介导的Gq信号抑制了ENaC的活性,促进了自然和降低了血压.
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