在美国成年人中,阻塞性睡眠呼吸暂停和COVID-19感染和住院治疗之间的关联
Stuart F Quan1,2, Matthew D Weaver1,2, Mark É Czeisler3,4,5
1Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
概括
阻塞性睡眠呼吸暂停 (OSA) 在一般人群中增加了COVID-19感染和住院的风险. 接种COVID-19疫苗,特别是提升状态,提供了保护,并可以降低与OSA相关的住院风险.
科学领域:
- 睡眠医学 睡眠医学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 医学并发症是已知的严重COVID-19的风险因素.
- 阻塞性睡眠呼吸暂停 (OSA) 已被建议增加COVID-19风险,但在一般人群中证据有限.
研究的目的:
- 调查阻塞性睡眠呼吸暂停 (OSA) 与美国普通成年人群中COVID-19感染和住院的几率之间的关联.
- 为了确定COVID-19疫苗接种状态是否会改变OSA和COVID-19结果之间的关系.
主要方法:
- 在15057名美国成年人中进行了一项横截面调查.
- 后勤回归模型被用于分析OSA和COVID-19感染/住院之间的关联,并根据各种人口,社会经济和医疗因素进行调整.
主要成果:
- 阻塞性睡眠呼吸暂停 (OSA) 与 COVID-19 感染 (aOR: 1.58) 和住院 (aOR: 1.55) 的几率增加有关.
- 提升的COVID-19疫苗接种状态对感染和住院均有保护作用.
- 强化疫苗接种减弱了OSA-COVID-19住院联系,但没有感染;未经治疗/有症状的OSA构成最高风险.
结论:
- 阻塞性睡眠呼吸暂停 (OSA) 与一般人群中COVID-19感染和住院率较高有关.
- 这种联系在未经治疗或有症状的OSA患者中最为明显.
- 接种COVID-19疫苗,特别是提升状态,可以减轻风险,特别是住院治疗.
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