肠道微生物群在肝脑病变中的病变由肠 - 肝 - 脑轴引起
Ruirui Zhu1,2, Liwen Liu1,2,3, Guizhen Zhang1,2,3
1Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Bioscience reports
|June 6, 2023
概括
肝发性脑病 (HE) 涉及肠-肝-脑轴功能障碍,肠道微生物群的变化有助于高血. 恢复微生物平衡,可能通过便微生物群移植 (FMT),为HE患者的认知障碍提供了有前途的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 肝性脑病变 (HE) 是肝硬化的一种神经并发症.
- 由肠道衍生的氨驱动的超氨血是HE病变的核心原因.
- 肠 - 肝 - 脑轴,涉及阴道通路,介导HE进展.
研究的目的:
- 阐明肠道微生物群在肝脏脑病变中的作用.
- 探索针对肠道微生物组进行HE治疗的治疗策略.
主要方法:
- 关于HE病原和肠道微生物组变化的当前文献的综述.
- 在HE中分析肠道微生物组成和功能的变化.
- 评估微生物组调节疗法,如益生菌,益生菌,抗生素和FMT.
主要成果:
- 肝硬化向HE的进展与失生症有关:有益细菌减少和致病细菌过度生长.
- 肠道微生物群的改变有助于减少短链脂肪酸和胆酸的产生,增加肠道透性和细菌转移.
- 便微生物群移植 (FMT) 成为恢复微生物平衡的新方法.
结论:
- 肠道微生物群失生症在肝脏脑病变的发展和进展中起着至关重要的作用.
- 针对肠道微生物群,特别是通过FMT,具有显著的潜力,可以改善HE患者的认知功能.
- 恢复肠道微生物平衡是管理HE的可行的治疗策略.
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