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抗脂综合征患者中炎症和补充激活生物标志物的相关性,除了急性血栓形成外

Cecile M Yelnik¹, Marc Lambert², Elodie Drumez³

¹Département de Médecine Interne et d'Immunologie Clinique, Centre National de Référence Maladies Systémiques et Auto-immunes Rares Nord et Nord-Ouest de France (CeRAINO), European Reference Network on Rare Connective Tissue and Musculoskeletal Diseases Network (ReCONNECT), Université de Lille, CHU Lille; and INSERM, UMR 1167, RID-AGE, Lille, France. cecile.yelnik@orange.fr.

Clinical and experimental rheumatology

|June 6, 2023

概括

抗脂综合征 (APS) 患者可以分为"炎症性"和"补充性"群. 介乐-6 (IL-6) 与心血管风险相关,而Bb片段与抗脂抗体 (aPL) 概况和严重疾病风险相关.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
临床医学临床医学

背景情况:

抗脂综合征 (APS) 是一种自身免疫性疾病,其特征是复发性血栓形成和怀孕发病率.
炎症和补充通路在APS病原和临床表现中的作用需要进一步阐明.

研究的目的:

研究特定的炎症和补充生物标志物与APS的临床特征之间的关联.
探索基于生物标志物概况的APS患者的潜在集群.

主要方法:

测量了各种细胞因子 (IL-1β,IL-6,IL-8,IL-10,TNF-α,IFN-α,IFN-γ) 和粘附分子 (VEGF,ICAM-1,E-selectin,VCAM-1) 的血清水平.
补充成分 (sC5b-9,C3a,C4a,Bb片段) 的血水平在98名APS患者和25名健康对照中得到量化.
集群分析用于根据生物标志物水平确定患者子组.

主要成果:

与对照组相比,APS患者的IL-6,VCAM-1,sC5b-9,C3a,C4a和Bb水平显著增加.
集群分析确定了两个不同的群体:"炎症性"集群 (高IL-6,VCAM-1) 和"补充"集群.
升高的IL-6与高血压,糖尿病,BMI和高甘油三血症有关. Bb片段的升高与抗脂抗体 (aPL) 阳性强烈相关,特别是三重aPL阳性,以及灾难性的APS病史.

结论:

在急性血栓形成之外的APS患者可以分为"炎症"和"补充"群.
升高的IL-6与心血管风险因素和APS中的代谢参数有关.
标志着替代补充通路激活的Bb片段与aPL特征相关,并增加了严重APS结果的风险.

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