讲宿主语言:沙门氏菌效应蛋白如何操纵宿主
Timesh D Pillay1,2, Sahampath U Hettiarachchi3,4, Jiyao Gan3
1Centre for Bacterial Resistance Biology, Department of Infectious Disease, Imperial College, London SW7 2AZ, UK.
Microbiology (Reading, England)
|June 6, 2023
概括
沙门氏菌细菌向宿主细胞注入超过40种毒性因子,其中许多介导后翻译修饰 (PTM) 来改变感染结果. 本次审查评估了这些沙门氏菌因子及其对宿主细胞的影响.
科学领域:
- 微生物学 微生物学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 沙门氏菌使用超过40种通过III型分泌系统传递的效应蛋白来操纵宿主细胞过程.
- 有相当数量的这些效应因子 (至少25个) 介导宿主蛋白质的真核生物样后翻译性修饰 (PTM).
结论:
- 沙门氏菌对宿主PTM的操纵是病变发生的一个关键机制.
- 需要进一步的研究来描述许多鲜为人知的沙门氏菌效应因子的功能.
- 了解这些作用因子,可以了解细菌的毒性和潜在的治疗点.
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